Appendix 2: Potential drug interactions of apixaban
Acute Oncology Guidelines
Warning
Potential drug interactions of apixaban45
| CYP3A4 and P-glycoprotein interactions | Examples | Potential interaction with apixaban |
| Strong inhibitors of both CYP3A4 and P-gp | ketoconazole, itraconazole, voriconazole, HIV protease inhibitors (e.g. ritonavir) |
Can increase apixaban concentrations. Potential for increased bleeding risk. |
| Strong inducers of both CYP3A4 and P-gp | phenytoin, carbamazepine, phenobarbital or St. John's Wort |
Can reduce apixaban concentrations. Efficacy of apixaban may be compromised. |
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For further information consult the apixaban SMPCÂ |
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