Necrotising Fasciitis

Antimicrobial prescribing: NHS Borders
NHS Borders

First Line

Therapy

Flucloxacillin IV 2g 6 hourly

+

Ciprofloxacin IV 400mg 12 hourly (IV for 1st dose, then review if appropriate to switch patient to oral).

+

Clindamycin IV 600mg to 1.2g 6 hourly

Notes:

Penicillin Allergy

Therapy

Vancomycin IV (dosing as per guideline. Use vancomycin calculator)

+

Ciprofloxacin IV 400mg 12 hourly (IV for 1st dose, then review if appropriate to switch patient to oral).

+

Clindamycin IV 600mg to 1.2g 6 hourly

Notes:

Notes

Discuss with Consultant Microbiologist.

 

Fluroquinolones

Refer to important safety information for all quinolones prior to prescribing.

See MHRA Drug Safety Update January 2024: Fluoroquinolones must only be used in situations when other antibiotics, that are commonly recommended for the infection, are inappropriate such as:

  • there is resistance to other first-line antibiotics recommended for the infection
  • other first-line antibiotics are contraindicated in an individual patient
  • other first-line antibiotics have caused side effects in the patient requiring treatment to be stopped

treatment with other first-line antibiotics has failed