Important: Therapy
Amoxicillin 500mg PO 8 hourly AND *Nitrofurantoin 100mg MR PO 12 hourly or Trimethoprim 200mg PO 12 hourly
(Check previous cultures and sensitivities)
*Nitrofurantoin is contra-indicated in patients with an eGFR < 45ml/min however a short course (3-7 days) may be used with caution in patients with an eGFR 30-44ml/min with suspected or proven multidrug resistant pathogens. Toxic plasma concentrations can occur particularly in the elderly causing adverse effects eg neuropathy, blood dyscrasias