Pyelonephritis/ Urosepsis

Important: Therapy

• Samples should be taken prior to starting treatment.
• Send blood for culture if pyrexial.

Notes:

Important: Therapy

Gentamicin^¥ IV (Hartford Regimen) as per guideline

Use preferred calculator on Hospital portals page [intranet access only] or calculator on app

NB: if reduced or unstable renal function give single dose only then review with Infectious Diseases or Microbiology

PLUS Amoxicillin 1g IV 8 hourly

 

Switch to oral option guided by microbiology sensitivities

Notes:

^¥If > 72 hours IV therapy required replace gentamicin with temocillin IV 2g 12 hourly.

Important: Therapy

Ciprofloxacin 500mg oral (or 400mg IV) 12 hourly

Switch to alternative oral option if indicated by microbiology sensitivities.

Notes:

Avoid ciprofloxacin in frail elderly patients where possible due to CDI risk. Check important safety information in BNF & give MHRA patient information leaflet to patient