Aztreonam IV

Permitted indications

May be used for the following indications:

1. As an alternative to gentamicin for patients with CrCl < 30mL/min (CKD≥4) or known or suspected Acute Kidney Injury (AKI) in previous 48 hours (≥50% increase in baseline serum creatinine or oliguria > 6 hours) being treated empirically for sepsis of unknown origin.
2. As an alternative to gentamicin for high risk patients with CrCl < 30mL/min (CKD≥4) or known or suspected AKI in previous 48 hours (≥50% increase in baseline serum creatinine or oliguria > 6 hours) being treated empirically for neutropenic sepsis.
3. On the advice of a Medical Microbiologist or Infection Specialist for treatment of gram-negative infections.

Refer to: NHS Grampian Guidance On The Use Of Aztreonam