Infectious diseases
- Doses at 0, 1 and 2 months (alternatively, 0, 7 & 21 days if more pragmatic) with a booster dose at 12 months.
- See current BNF for adult and paediatric doses.
Post-exposure prophylaxis (PEP) for Hepatitis B
See the needlestick injury immediate care and BBV risk assessment flowchart for recommended actions.
Most HCWs are vaccinated against HBV (and may know their anti-HBs titre). Irrespective of type of exposure:
- All fully vaccinated HCWs should be offered a HBV booster
- All non/partially vaccinated HCWs should start/complete a course of HBV vaccine. Those with previous HBV infection require no prophylaxis.
Where indicated, give HBIG as soon as possible and ideally within 48hrs (but can be considered up to a week post-exposure).
HBIG is held in the RIE Emergency department. Dose:
- Adult and child over 10yrs, 500IU by IM injection
- Children <10yrs: contact the paediatric ID consultant at RHCYP (Unavailable: See Where to get expert advice). Do not co-administer HBIG and HBV vaccine at the same site.
- Those with Significant Exposure should be referred for follow-up testing.
- Follow up testing should be scheduled as per Table 1.
- Follow up everyone who received a course of vaccine.
- Individuals don’t need follow-up HBV testing if they are pre-exposure vaccine responders, and anti-HBS titre >100mIU/ml 2-3 months after a full course of vaccine.