Penicillin allergy and cross-sensitivity
NHS Dumfries & Galloway Antimicrobial Handbook
Warning
- Penicillins (and all beta lactams) should be avoided in those who have a true allergy (anaphylaxis) - this occurs in under 1% of patients
- Penicillin allergy is documented in over 10% of patients but the nature of allergy is often uncertain (not a true allergy)
- Cross sensitivity between penicillins and 1st/2nd generation cephalosporins has been reported in up to 10% and for 3rd generation cephalosporins 2-3% of patients
- Cephalosporins should be avoided in those who have a true penicillin allergy (anaphylaxis)
- Cephalosporins may be used with caution in patients with mild sensitivity to penicillin (e.g. develop a rash)
- Confirm the nature of a drug allergy with the patient as it is often not a true allergy