Tranaxemic acid

North of Scotland major trauma guidelines
NHS Grampian

Based on CRASH2 trial results.

 

Indications

  • Significant haemorrhage and SBP <90mmHg or HR >110bpm.
  • At risk of significant haemorrhage.

 

Relative Contraindication

  • History of thromboembolic disease.
  • >3 hours from injury unless hyperfibrinolysis is demonstrated on ROTEM.

Administer 1g bolus over 10 minutes followed by 1g infusion over 8 hours.

The infusion can be omitted/stopped in the following patients:

  • No evidence of haemorrhage, or
  • Haemorrhage controlled with a normal ROTEM.