ACE inhibitor (Enalapril 2.5 - 20mg/day (uptitrated as tolerated) vs placebo, heart failure

Study population:

Patients with heart failure

(NYHA class I - IV) due to left ventricular systolic dysfunction (ejection fraction ≤0.35).

Comments:

Mean age of patients was 61 years, approximately 80% were male. Less than 2% were NYHA Class IV.

Treatment also reduced hospital admissions for heart failure.

Mortality benefit appears to be most marked in the first 24 months of treatment.