ACE inhibitor (Enalapril 2.5 - 40mg/day (uptitrated as tolerated) vs placebo, asymptomatic heart failure
Polypharmacy guidance: realistic prescribing
Study population:
Patients with asymptomatic heart failure (NYHA class I) due to left ventricular systolic dysfunction (ejection fraction ≤0.35)
Comments:
Mean age of enrolled patients was 60 years.
Treatment reduced the incidence of congestive heart failure and related hospital admissions
| Outcome | Duration | NNT | Annualised NNT |
|---|---|---|---|
| Prevent one death (any cause) | 34 months(mean followup) |
88 |
251 |