Angiotensin II receptor blocker (Candesartan 4-32mg/day)
Polypharmacy guidance: realistic prescribing
Study population:
Patients with intolerance to ACE inhibitors with symptomatic heart failure
(NYHA Class II-IV) and ejection fraction ≤0.4.
Comments:
Mean age of enrolled patients was approximately 66 years.
Patients were already taking other drugs as part of therapy for heart failure. Approximately 70% had heart failure of ischaemic cause.
| Outcome | Duration | NNT | Annualised NNT |
|---|---|---|---|
|
Prevent one death (cardiovascular cause) or hospital admission for chronic heart failure |
33.7 months |
14 |
40 |
| Prevent one death | 33.7 months |
34 |
94 |