Betablocker (Bisoprolol titrated to target dose of 10mg/day) vs placebo

Study population:

Patients with moderate to severe heart failure NYHA III-IV  LVEF ≤ 0.35 were enrolled

Comments:

Mean age of patients was 61 years, 83% of which were NHYA III.

Current treatment had to include a diuretic and an ACE inhibitor although other vasodilators were allowed if patients were intolerant of ACE inhibitors. 96% of patients were on ACE inhibitors.