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  6. Direct Acting Oral Anticoagulants (DOACs)
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Direct Acting Oral Anticoagulants (DOACs)

Polypharmacy guidance: realistic prescribing
Scottish Government Effective Prescribing & Therapeutics Division
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About Direct Acting Oral Anticoagulants (DOACs)

Antiplatelet, placebo or no treatment

Apixaban 5mg twice daily vs Warfarin - stroke or systemic embolism

Apixaban 5mg twice daily vs Warfarin - major bleeding

Aspirin vs placebo or no treatment

Aspirin or other antiplatelet vs placebo or no treatment

Aspirin & Dipyridamole vs placebo

Aspirin & Dipyrdamole vs aspirin

Dabigatran 110mg or 150mg twice daily vs Warfarin - stoke or systemic embolism

Dabigatran 110mg or 150mg twice daily vs Warfarin- major bleeding

Edoxaban mg or 60mg daily vs Warfarin - stroke or systemic embolism

Edoxaban mg or 60mg daily vs Warfarin - major bleeding

Rivaroxaban 20mg daily vs Warfarin - stoke or systemic embolism

Rivaroxaban 20mg daily vs Warfarin - major bleeding

Statin vs placebo, stroke

Statin vs placebo, serious vascular events

Thienopyridine derivative (Ticlopidine or Clopidogrel) vs Aspirin, stroke (all types)

Thienopyridine derivative (Ticlopidine or Clopidogrel) vs Aspirin, stroke, MI or vascular death

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