Thienopyridine derivative (Ticlopidine or Clopidogrel) vs Aspirin, stroke, MI or vascular death

Polypharmacy guidance: realistic prescribing
Scottish Government Effective Prescribing & Therapeutics Division
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Study population:

Secondary prevention of CVD in patients with history of ischaemic stroke or TIA.

Comments:

Mean age of patients was 63 years.

Ticlopidine is not available in the UK but has similar mode of action to clopidogrel

Outcome Duration NNT Annualised NNT

Stroke, MI or vascular death

 28 months

 100

223
References

The Cochrane Collaboration. Thienopyridine derivatives versus aspirin for preventing stroke and other serious vascular events in high vascular risk patients.  The Cochrane Library 2009, Issue 4