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Powder for solution for infusion 200mg (specialist use only)
As per SMC2273: For adult patients treated with a direct factor Xa (FXa) inhibitor (apixaban or rivaroxaban) when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.
Solution for injection/infusion (Praxbind®) 2·5g/50mL (specialist use only)
As per SMC 1178/16: idarucizumab is a specific reversal agent for dabigatran and is indicated in adult patients treated with dabigatran etexilate when rapid reversal of its anticoagulant effects is required for emergency surgery/urgent procedures or in life-threatening or uncontrolled bleeding.
For reversal of warfarin anticoagulation seek advice from Consultant Haematologist.
Prothrombin complex is used in addition to vitamin K in patients who are bleeding and on warfarin or who are anticoagulated and requiring urgent surgery. It provides temporary but immediate reversal of anticoagulation and can be obtained from the Blood Transfusion Service on the authorisation of a Haematologist.
Injection 10mg/mL (specialist use only)
Injection, in a mixed micelles vehicle (Konakion® MM Paediatric) 2mg/0·2mL
Patients with abnormal coagulation due to vitamin K deficiency or patients on warfarin who are bleeding or who have a high INR. It may take up to 6 to 12 hours to act. The dose and route of administration depends on the indication; if in doubt, discuss with the Consultant Haematologist.
Konakion®MM Paediatric can be administered by intramuscular, intravenous or oral route.
(Konakion® MM) 10mg/1mL
Patients with abnormal coagulation due to vitamin K deficiency or patients on warfarin who are bleeding or who have a high INR. It may take up to 6 to 12 hours to act. The dose and route of administration depends on the indication; if in doubt, discuss with the Consultant Haematologist.
Protamine sulfate is capable of partially reversing the anticoagulant activity of unfractionated heparin. It is of limited value in the reversal of low molecular weight heparin (enoxaparin) and of no value in the reversal of warfarin, dabigatran, rivaroxaban or apixaban. It is contra-indicated in patients with fish allergy.
Injection 50mg/5mL (specialist use only)
TAM (Treatments and Medicines) NHS Highland