Thiazides and related diuretics (Formulary)

TAM (Treatments and Medicines) NHS Highland
NHS Highland

BENDROFLUMETHIAZIDE

Therapy notes

Formulation and dosage details

Formulation:

Tablets 2.5mg, 5mg

Dosage:

Hypertension - 2·5mg daily in the morning
Heart failure - 2·5 to 5mg daily
Oedema - initially 5 to 10mg daily in the morning or on alternate days, maintenance 5 to 10mg 1 to 3 times weekly.

Notes:

Bendroflumethiazide 2·5mg daily may be used in many cases of mild to moderate hypertension and higher doses are rarely necessary.

INDAPAMIDE

Therapy notes

Indapamide is the first-line thiazide in NICE CG127 Hypertension in adults; diagnosis and management.
For use post-TIA or ischaemic stroke refer to guidance.

Formulation and dosage details

Formulation:

Tablets 2·5mg

Dosage:

2·5mg daily in the morning. 

METOLAZONE

Therapy notes

MHRA advice: Metolazone (Xaqua) 5mg tablets: exercise caution when switching patients between metolazone preparations (January 2023) (www.gov.uk).

  • Use with caution long-term due to the risk of renal impairment.

Formulation and dosage details

Formulation:

Tablets 5mg (specialist initiation/recommendation only)

Dosage:

Initially, 2·5mg (unlicensed) to 5mg in the morning for 3 days then review; may be administered on alternate days. 

Editorial Information

Document Id: F042