Catechol-O-methyltransferase inhibitors (Formulary)

TAM (Treatments and Medicines) NHS Highland
NHS Highland

ENTACAPONE

Therapy notes

  • Note: Entacapone may cause:

    • urine to be coloured reddish-brown
    • gastro-intestinal upset, particularly diarrhoea.

Formulation and dosage details

Formulation:

Tablets 200mg (s)

Dosage:

200mg at the same time as each dose of co-beneldopa or co-careldopa, maximum 2 grams daily.

LEVODOPA WITH CARBIDOPA AND ENTACAPONE

Therapy notes

Formulation and dosage details

Formulation:

Tablets (Stanek®) 50/12·5/200, 75/18·75/200, 100/25/200, 125/31·25/200, 150/37·5/200, 175/43·75/200, 200/50/200 (mg) (equivalent to Stalevo®) (s)

OPICAPONE

Therapy notes

Formulation and dosage details

Formulation:

Hard capsules 50mg (under specialist direction only)

Dosage:

See SMC advice 2430: as adjunctive therapy to preparations of levodopa/DOPA decarboxylase inhibitors (DDCI) in adult patients with Parkinson’s disease and end-of-dose motor fluctuations who cannot be stabilised on those combinations.

Editorial Information

Document Id: F093