Drugs that enhance neuromuscular transmission (Formulary)

TAM (Treatments and Medicines) NHS Highland
NHS Highland

Neostigmine, pyridostigmine and immunosuppressants, eg prednisolone (Corticosteroids), azathioprine (Drugs affecting the immune response), are used to treat myasthenia gravis, whereas edrophonium is used in the diagnosis.

PYRIDOSTIGMINE

Therapy notes

  • Gastro-intestinal side-effects are common and can be treated with the antimuscarinic propantheline bromide (non-Formulary).

Formulation and dosage details

Formulation:

Tablets 60mg

Dosage:

By mouth, 30 to 120mg at suitable intervals throughout day. Doses exceeding 360mg daily should only be prescribed in consultation with a specialist.  

EDROPHONIUM

Therapy notes

  • Stock is held in Raigmore Hospital emergency drug cupboard.

Formulation and dosage details

Formulation:

Injection 10mg/mL unlicensed (s)

NEOSTIGMINE

Therapy notes

Formulation and dosage details

Formulation:

Injection 2·5mg/mL (s)

Editorial Information

Document Id: F281